Randomized clinical trial of intrapartum clindamycin cream for reduction of group B streptococcal maternal and neonatal colonization

Randomized Clinical Trial of Intrapartum Clindamycin Cream for Reduction of Group B Streptococcal Maternal and Neonatal Colonization

OBJECTIVE In a randomized trial, we sought to determine whether 2% clindamycin cream administered intravaginally during labor to group B streptococcal-colonized pregnant women without risk factors would decrease maternal and neonatal colonization. METHODS The eligible women were randomized to receive either cream or no treatment. Two hours after treatment or admission, the patients were teste...

Maternal and neonatal group B streptococcal bacteriuria.

Relationship between Colonization of Group B Streptococcal (GBS) in the Reproductive System of Pregnant Women with PCR with Neonatal and Maternal Complications

Background and Aim: Group B Streptococcus (GBS) is a major contributor to maternal and neonatal death. GBS colonization in the mother can be transient or intermittent, which is why its examination during delivery is more valuable than screening at lower gestational age. The aim of this study was to compare the complications of premature delivery with term ones in positive cases of GBS by PCR me...

Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches

Group B Streptococcus (GBS) colonizes the gastrointestinal and vaginal epithelium of a significant percentage of healthy women, with potential for ascending intrauterine infection or transmission during parturition, creating a risk of serious disease in the vulnerable newborn. This review highlights new insights on the bacterial virulence determinants, host immune responses, and microbiome inte...

Randomized, Placebo-Controlled Trial of Transplacental Antibiotic Prophylaxis of Neonatal Group B Streptococcal Colonization and Bacteremia in Rabbits

OBJECTIVE We evaluated the effect of maternal administration of ampicillin/sulbactam on colonization and bacteremia in newborn rabbits after intracervical inoculation of mothers with group B streptococci (GBS). METHODS New Zealand white rabbits on day 30 of a 31-day gestation were inoculated intracervically with 10(4)-10(5) colony forming units (cfu) GBS. Two hours after inoculation mothers r...